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. 2014 Sep 30;5:370. doi: 10.3389/fphys.2014.00370

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Copyright © 2014 Navarro, Borroto-Escuela, Fuxe and Franco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme of caveolins/caveolae participation in the cell biology of GPCRs. Caveolins/caveolae regulate agonist binding and signaling and GPCR traffic. Some interventions with therapeutic potential are: (A) targeting caveolin-binding domains in the GPCR. (B) Regulating synthesis and expression of caveolins by means of cell therapy or small interfering RNA. (C) Targeting receptors to regulate caveolae-dependent endocytosis. (D) Regulation of cholesterol levels, for instance by using statins.