Table II.
Post hoc analysis of LGALS2 3279C>T with the risk of CAD in various ages and gender.
| Age, years | Gender | Group | Genotype (CC/CT/TT) | χ2 | P-value (df=2) | HWE | Allele (C/T) | χ2 | P-value (df=1) | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| ≤55 | Male | CAD case (n=103) | 65/32/6 | 0.45 | 162/44 | |||||
| Controls (n=137) | 86/44/7 | 0.07 | 0.96 | 0.66 | 216/58 | 0.003 | 0.96 | 1.01 (0.65–1.57) | ||
| Female | CAD case (n=32) | 16/15/1 | 0.25 | 47/17 | ||||||
| Controls (n=65) | 40/19/6 | 3.51 | 0.17 | 0.12 | 99/31 | 0.17 | 0.68 | 1.16 (0.58–2.29) | ||
| 55–65 | Male | CAD case (n=141) | 80/57/4 | 0.10 | 217/65 | |||||
| Controls (n=98) | 63/30/5 | 2.87 | 0.24 | 0.57 | 156/40 | 0.47 | 0.49 | 1.09 (0.64–1.86) | ||
| Female | CAD case (n=51) | 27/21/3 | 0.68 | 75/27 | ||||||
| Controls (n=117) | 62/52/3 | 1.18 | 0.55 | 0.04 | 176/58 | 0.11 | 0.74 | 1.09 (0.64–1.86) | ||
| ≥65 | Male | CAD case (n=156) | 97/49/10 | 0.27 | 243/69 | |||||
| Controls (n=85) | 44/36/5 | 2.91 | 0.23 | 0.50 | 124/46 | 1.48 | 0.22 | 0.76 (0.50–1.18) | ||
| Female | CAD case (n=79) | 52/24/3 | 0.91 | 128/30 | ||||||
| Controls (n=70) | 40/28/2 | 1.53 | 0.46 | 0.26 | 108/32 | 0.67 | 0.41 | 0.79 (0.45–1.38) |
LGALS2, lectin galactoside-binding soluble-2; CAD, coronary artery disease; df, degrees of freedom; HWE, Hardy-Weinberg equilibrium; OR, odds ratio; 95% CI, 95% confidence interval.