Plasma perindopril concentration in combination with Chungsinoryungsan (CSORS) at 2-h interval. The combination group received a repeated co-administration of perindopril in combination with CSORS for a week at 2-h interval (open circles, n=5) and the corresponding control received perindopril with distilled water (closed circles, n=5). The plasma samples were assessed at 0.5, 1, 2, 3, 4, 6, 8 and 24 h after (A) the initial and (B) last co-administration of the repeated dosing. All the data represent average values (ng/ml) ± SEM.