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. 2014 Sep 30;5:475. doi: 10.3389/fimmu.2014.00475

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Copyright © 2014 Alural, Duran, Tufekci, Allmer, Onkal, Tunali, Genc and Genc.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EPO may enhance neurite outgrowth and length via regulation of miR-451 and miR-885-5p. Transfected and non-transfected cells were treated with 1 U/ml EPO. (A) Neurite cell number was counted using ImageJ 1.42 (http://imagej.nih.gov/ij/). Randomly selected fields in microscopic analysis with an average of 35 cells per field were analyzed. (B) Representative phase-contrast microscopy images are shown in order to indicate the increased neurite numbers induced by EPO and reversed by the transfection of mimics of miR-451 and miR-885-5p. (C) The average maximal neurite length for both, the transfected and non-transfected cells were analyzed by ImageJ 1.42 (http://imagej.nih.gov/ij/). At least 30 neurites per condition were measured. (D) Neurite length distribution. Arrowheads indicate the neurites arising from cells. Scale bar, 100 μm. EPO, erythropoietin. The data are presented as mean ± SE, n = 5 (*p < 0.05).