Figure 2.

The experimental protocol. All mice were subjected to a 9 week UCMS. After 2 weeks of UCMS, a dexamethasone suppression test was performed. 3 weeks later, mice were divided in two cohorts according to their level of corticosterone suppression. The UCMS procedure continued 5 further weeks. In each cohort, half of the mice were treated daily with vehicle while the other half was daily treated with fluoxetine (ip, 15 mg/kg/per day). At the end, behavioral tests were performed as well as a second dexamethasone suppression test. HS: High suppresser, LS: Low suppresser, VEH: vehicle, FLX: fluoxetine.