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. 2014 Sep 30;8:340. doi: 10.3389/fnbeh.2014.00340

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Copyright © 2014 Khemissi, Farooq, Le Guisquet, Sakly and Belzung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of UCMS and 4 weeks treatment of fluoxetine (FLX 15 mg/kg/day ip) on cell proliferation and neurogenesis in the hippocampus. HS: High suppressers, LS: Low suppressers, VEH: vehicle, FLX: fluoxetine. (A) Densitiy of cell proliferation using ki-67 staining in the granule cell layer in the whole, dorsal, intermediate, and ventral hippocampus (whole, temporal and intermediate hippocampus: HS VEH (n = 9), HS FLX (n = 6), LS VEH (n = 7), LS FLX (n = 6); septal hippocampus: HS VEH (n = 7), HS FLX (n = 6), LS VEH (n = 7), LS FLX (n = 5)). (B) Density of immature neurons using doublecortin (DCX) labeling in the GCL (whole, temporal and intermediate parts: HS VEH (n = 5), HS FLX (n = 6), LS VEH (n = 6), LS FLX (n = 4); septal parts: HS VEH (n = 5), HS FLX (n = 5), LS VEH (n = 6), LS FLX (n = 4)). HS VEH vs. HS FLX: ^# p < 0.05, ^### p < 0.001; HS FLX vs. LS FLX: * p < 0.05, ** p < 0.01.