Table S1.
Serum biochemical analysis of rats
| A
| |||||||
|---|---|---|---|---|---|---|---|
| Animal groups | Kidney function test
|
||||||
| Sodium (mM/L) |
Potassium (mM/L) |
Chloride (mM/L) |
Co2 (mM/L) |
Anion gap (mM/L) |
Urea (mM/L) |
Creatinine (μM/L) |
|
| Vehicle | 138.66±0.76 | 3.7±0.01 | 100.21±0.33 | 25.9±0.44 | 13.3±0.56 | 5.32±0.47 | 32.15±1.76 |
| FALHE (2 g/kg) | 142.21±0.51 | 4.1±0.3 | 101.24±0.4 | 27.78±0.98 | 15.5±0.64 | 6.13±0.54 | 30.21±1.27 |
| FALHE (5 g/kg) | 140.21±0.77 | 4.0±0.02 | 105.27±0.33 | 25.26±0.8 | 16.15±0.44 | 6.99±0.29 | 30.15±1.19 |
| B
| ||||||||
|---|---|---|---|---|---|---|---|---|
| Animal groups | Liver function test
|
|||||||
| Total protein (g/L) |
Albumin (g/L) |
Globulin (g/L) |
TB (μmol/L) |
AP (U/L) |
ALT (U/L) |
AST (U/L) |
GGT (U/L) |
|
| Vehicle | 70.6±1.6 | 39.9±0.9 | 29.7±1.8 | 1.1±0.05 | 161.5±5.7 | 30.9±1.4 | 24.2±2.8 | 0.45±0.07 |
| FALHE (2 g/kg) | 67.9±1.8 | 38.5±0.3 | 30.6±1.2 | 1.4±0.06 | 163.8±4.1 | 35.5±1.7 | 25.48±2.9 | 0.57±0.09 |
| FALHE (5 g/kg) | 69.7±1.6 | 38.7±0.9 | 31.5±1.5 | 1.4±0.04 | 163.3±5.2 | 36.7±1.8 | 27.7±4.2 | 0.6±0.03 |
| C
| |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Animal Groups | Hematological test
|
||||||||
| HGB (g/dL) |
HCT (%) |
RBC (106 cells/μL) |
MCV (fL) |
MCH (pg) |
MCHC (g/dL) |
RDW (%) |
WBC (103/μL) |
Platelet (103/μL) |
|
| Vehicle | 16.03±0.7 | 39±0.00 | 9.3±0.1 | 60.2±0.5 | 17.5±0.3 | 33.34±0.7 | 14.1±0.4 | 6.2±0.4 | 999.5±32.5 |
| FALHE (2 g/kg) | 16.27±0.9 | 39±0.00 | 9.4±0.2 | 61.4±0.6 | 16.9±0.6 | 33.01±0.5 | 12.23±0.1 | 6.0±0.3 | 975.3±35.2 |
| FALHE (5 g/kg) | 16.38±0.2 | 38±0.00 | 9.3±0.1 | 59.8±0.7 | 15.9±0.9 | 32.93±0.9 | 12.7±0.4 | 5.9±0.2 | 969.2±23.8 |
Notes: Serum biochemical analysis of rats did not show any sign of FALHE toxicity on (A) renal function test, (B) liver function test, and (C) hematological parameters of the rodents, when compared with the control group. Values expressed as mean±standard deviation.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; AP, alkaline phosphatase; GGT, G-glutamyl transferase; HCT, hematocrit; HGB, hemoglobin; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; RBC, red cell count; RDW, red cell distribution width; TB, total bilirubin; WBC, white cell; FALHE, Ferulago angulata leaves hexane extract.