Figure 3.

Effect of cisplatin on the relative tension of endothelium-denuded thoracic aorta. (A) Cisplatin decreased the relative tension of endothelium-denuded rat thoracic aortic rings precontracted with KCl at the resting tension of 2 g in an ex vivo perfusion system in a time-dependent manner. (B) Cisplatin inhibited the contraction induced by phenylephrine in endothelium-denuded rat thoracic aortic rings at 6 h. Data are expressed as mean ± SEM. ^*P<0.05 versus control endothelium-denuded aorta rings.