Table III.

Cytokine concentrations in the brain of uninfected mice and mice infected systemically with C. albicans at 24 and 72 h post-infection by cytometric bead array analysis.

Brain	Uninfected group, mean ± SEM	24 h post-infection with C. albicans		72 h post-infection with C. albicans
		Mean ± SEM	P-value	Mean ± SEM	P-value
IFN-γ	1.33±1.33	5.68±2.64	0.182	1.33±1.33	0.902
IL-10	80.87±45.72	162.20±2.48	0.170	25.66±16.26	0.532
IL-17a	7.39±2.47	1.54±1.54	0.090	2.54±1.61	0.104
IL-2	17.28± 3.23	20.28±4.78	0.057	7.98±3.60	0.060
IL-4	0.00±0.00	9.25±4.41	0.462	0.00±0.00	1.000
IL-6	2.72±2.72	88.53±8.32	0.004	747.90± 500.40	0.004
TNF-α	3.61±3.61	69.53±13.40	0.006	1570±584.50	0.004

Results are expressed as mean ± standard error of the mean (SEM) and the concentration of each cytokine measured is expressed in pg/g of brain tissues. P<0.05 was considered to indicate a statistically significant difference. C. albicans, Candida albicans; IFN-γ, interferon-γ; IL, interleukin; TNF-α, tumor necrosis factor-α.