Table III.

Adverse events in the patients (n=53).

Adverse events	Grade (patient no.)				% of patients with grade 3–4 toxicity
	1	2	3	4
Skin rash	11	26	6	0	11.3
Diarrhea	16	1	1	0	1.9
Anorexia	14	6	5	0	9.4
Nausea	4	2	0	0	0.0
Vomiting	1	1	1	0	1.9
Fatigue	8	7	3	0	5.7
Stomatitis	10	2	1	0	1.9
Ocular disorders	2	0	1	0	1.9
ALT increased	7	4	1	2	5.7
AST increased	10	4	1	2	5.7
Amy increased	0	1	0	1	1.9
Leukopenia	1	1	0	0	0.0
Thrombocytopenia	6	0	0	0	0.0
ILD	2	0	1	0	5.6a (G3–5)

^aGrade 5 ILD was observed in 2 patients.

ALT, alanine transaminase; AST, aspartate transaminase; amy, amylase; ILD, interstitial lung disease.