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. 2014 Sep 27;12:273. doi: 10.1186/s12967-014-0273-3

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© Jiang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Galectin-3 overexpression promoted HCC cell invasion, whereas knockdown of galectin-3 suppressed these processes. (A) Knockdown of galectin-3 significantly inhibited cell invasion in Bel-7402, HepG2 cells, Hep3B and Huh7 cells. Images are shown on the left (magnification: ×100), and the quantification of 10 randomly selected fields is shown on the right. The results are expressed as three independent experiments (*P < 0.05, independent Student t test). (B) Galectin-3 promoted cell invasion in Hep3B cells. The results are expressed as three independent experiments (*P < 0.05, independent Student t test).