Figure 7.Interactions involving jIIIabc. (A) The docked model of jIIIabc (with IIIc and IIIa) (magenta) in complex with S27 (yellow) is shown fitted in the cryoEM density²² (gray). Locations of domain IIIc and bulge base G243 are also indicated. The fitted model of S7 (green) is also shown. (B) Structural alignment of human 40S S27 (yellow) and 60S ribosomal protein l40¹³ (green). The residues of l40 at the interface with rRNA are highlighted. (C) Residue-base interactions involving HCV IRES IIIef+pseudoknot and human 40S ribosomal proteins S27 and S7. Residue numbers are given below the protein names and interacting bases are highlighted. The site of interaction involving domain jIIIabc with respect to the complete ribosome, is indicated in the inset on the left.