Fig. 1.

Experimental paradigm. Rats were trained to walk on the DigiGait^™ system at 25 and 35 cm/s for 5 consecutive days. Initial behavioral assessments were conducted 2 days following training by recording baseline performance for 2 minutes at both speeds. At 2 days following initial recordings, animals were assigned randomly to either unlesioned (control) or lesioned groups, and the latter received injections of 3-AP/nicotinamide. All animals were reassessed 7 days later for 2 minutes at both speeds.