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. 2014 Sep 29;9(9):e108160. doi: 10.1371/journal.pone.0108160

Figure 7. Auditory testing of Gfi1-SOX2 mutants demonstrates that SOX2 expression causes hearing impairment.

Figure 7

A. Auditory brainstem recordings (ABRs, left) of Gfi1-SOX2 mutants and littermate controls at 5 weeks of age show that SOX2-expressing mice have significantly raised thresholds compared to controls. B. Measurements of distortion product otoacoustic emissions (DPOAEs) of the same mice tested for ABR, also show raised thresholds at 5 weeks. To determine significance, a 2-way ANOVA was performed, with pairwise comparisons to determine significance for each frequency: ** = p<0.001, * = p<0.05.