Table 4.
Risk factors for severe hypertriglyceridemia
| Factor | Total number of patients (%) | Peak TG >1000mg/dL (%) | Peak TG ≤1000 mg/dL (%) | P-value | |
|---|---|---|---|---|---|
| Age at diagnosis | <10 years | 188 (73.2%) | 6 (33.3%) | 182 (76.2%) | <.0001 |
| ≥10 years | 69 (26.8%) | 12 (66.7%) | 57 (23.8%) | ||
| Gender | Male | 145 (56.4%) | 13 (72.2%) | 132 (55.2%) | 0.16 |
| Female | 112 (43.6%) | 5 (27.8%) | 107 (44.8%) | ||
| Race | White | 196 (76.3%) | 15 (83.3%) | 181 (75.7%) | 0.76 |
| Black | 39 (15.2%) | 2 (11.1%) | 37 (15.5%) | ||
| Other | 22 (8.6%) | 1 (5.6%) | 21 (8.8%) | ||
| Initial WBC | <50,000 | 211 (82.1%) | 17 (94.4%) | 194 (81.2%) | 0.16 |
| ≥50,000 | 46 (17.9%) | 1 (5.6%) | 45 (18.8%) | ||
| BMI at diagnosis | Underweight/Healthy | 139 (54.1%) | 10 (55.6%) | 129 (69.4%) | 0.09 |
| Overweight/Obese | 65 (25.3%) | 8 (44.4%) | 56 (30.6%) | ||
| TGL at diagnosis* | Age Specific Normal | 31 (12.1%) | 2 (11.1%) | 29 (12.6%) | 0.38 |
| Age Specific Borderline High | 42 (16.3%) | 1 (5.6%) | 41 (17.7%) | ||
| Age Specific High | 176 (68.5%) | 15 (83.3%) | 161 (69.7%) | ||
| LDL at diagnosis | Normal (<110 mg/dL) | 215 (83.7%) | 13 (81.3%) | 202 (89.8%) | 0.52 |
| Borderline High (110–129 mg/dL) | 11 (4.3%) | 1 (6.3%) | 10 (4.4%) | ||
| High (>130 mg/dL) | 15 (5.8%) | 2 (12.5%) | 13 (5.8%) | ||
| HDL at diagnosis | Low (<40 mg/dL) | 233 (90.7%) | 18 (100.0%) | 215 (93.1%) | 0.51 |
| Borderline Low (40–45 mg/dL) | 10 (3.9%) | 0 (0.0%) | 10 (4.3%) | ||
| Normal (> 45 mg/dL) | 6 (2.3%) | 0 (0.0%) | 6 (2.6%) | ||
| Total cholesterol at diagnosis | Normal (<169 mg/dL) | 219 (85.2%) | 13 (72.2%) | 206 (89.2%) | 0.09 |
| Borderline High (170–199 mg/dL) | 20 (7.8%) | 3 (16.7%) | 17 (7.4%) | ||
| High (> 200 mg/dL) | 10 (3.9%) | 2 (11.1%) | 8 (3.5%) | ||
| Treatment arm | Low-risk | 97 (37.7%) | 1 (5.6%) | 96 (40.2%) | 0.0035 |
| Standard/High-risk | 160 (62.3%) | 17 (94.4%) | 143 (59.8%) | ||
| Peg-asparaginase randomization (LR arm) | 2500 units/m2 | 56 (56.6%) | 1 (100.0%) | 55 (56.1%) | 0.38 |
| 3500 units/m2 | 43 (43.4%) | 0 (0.0%) | 43 (43.9%) | ||
| Peg-asparaginase randomization (SR/HR arm) | 2500 units/m2 | 91 (57.6%) | 9 (52.9%) | 82 (58.2%) | 0.68 |
| 3500 units/m2 | 67 (42.4%) | 8 (47.1%) | 59 (41.8%) | ||
TGL: triglyceride; WBC: white blood cell count; BMI: body mass index; LDL: low-density lipoprotein; HDL: high-density lipoprotein; LR: low-risk; SR: standard-risk; HR: high-risk
*
Normal TGL levels (mg/dL):
- Age 0–9 years: Normal:
- <75; Borderline High: 75–99; High: ≥100
- Age 10–19 years: Normal: <90; Borderline High: 90–129; High: ≥130