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(A) mRNA pseudouridylation in eukaryotes is mediated by at least four conserved PUSs, some site specific (Pus1, Pus4, Pus7) and others snoRNA mediated (yeast Cbf5/human DKC1). (B) Pus7 may orchestrate the yeast mRNA pseudouridylation program in heat shock. At 30°, Pus7 is primarily nuclear, and its localization into the cytoplasm upon heat shock may induce mRNAs pseudouridylation.
