Table 5.
Improvement of Discrimination (C-Statistics) of 10-Year Risk Estimates for Addition of Growth Hormone to a Model With Conventional Cardiovascular Risk Factors
| Outcome | Sex | Basic (95% CI) | +GH (95% CI) |
|---|---|---|---|
| CAD | All | 0.748 (0.726–0.771) | 0.749 (0.726–0.772) |
| Male | 0.696 (0.665–0.726) | 0.698 (0.667–0.729) | |
| Female | 0.744 (0.707–0.782) | 0.744 (0.707–0.782) | |
| Stroke | All | 0.753 (0.726–0.780) | 0.757 (0.730–0.784) |
| Male | 0.745 (0.708–0.781) | 0.749 (0.712–0.785) | |
| Female | 0.749 (0.709–0.789) | 0.752 (0.713–0.791) | |
| CHF | All | 0.782 (0.739–0.825) | 0.786 (0.743–0.828) |
| Male | 0.784 (0.725–0.845) | 0.784 (0.724–0.844) | |
| Female | 0.789 (0.724–0.853) | 0.801 (0.737–0.865) | |
| Total mortality | All | 0.711 (0.691–0.730) | 0.714 (0.695–0.734) |
| Male | 0.700 (0.673–0.727) | 0.709 (0.683–0.736) | |
| Female | 0.703 (0.674–0.732) | 0.703 (0.674–0.733) | |
| Cardiovascular mortality | All | 0.783 (0.752–0.814) | 0.794 (0.763–0.825) |
| Male | 0.751 (0.705–0.797) | 0.764 (0.719–0.809) | |
| Female | 0.797 (0.751–0.844) | 0.807 (0.760–0.854) |
Harrell’s c-statistic. Area under the receiver-operating characteristics curve in basic model without hs-GH (basic) and the basic model with addition of hs-GH (+GH). Variables included in the original model: sex, age, systolic blood pressure, body mass index, antihypertensive medication, current smoking, diabetes mellitus, LDL-C, and HDL-C.