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Both IL26 and IFNG share requirements for CNS-30 for efficient expression. Transgenic IFNG-BAC WT, ΔCNS-30, and ΔCNS-16 CD4 T cells were stimulated with anti-CD3 and anti-CD28 under Th1 or Th17 polarizing conditions. After 5 days, cultures were harvested and restimulated with PMA and ionomycin for 6 hrs. Cultures were harvested and transcript levels of IL26, IFNG, and Ifng were determined as described in Figure 1. Results are expressed relative to WT BAC levels. Error bars are S.D.
