Table 4.
Association of maximal scores of five WOMAC pain items and sum of synovitis scores in three subregions on MRI, assessed by ordinal logistic regression model
| Summed synovitis scores in each subregion | Knees, N | Knees with pain, n (%)
|
Multi-adjusted model,§ OR (95% CI)
|
|||||
|---|---|---|---|---|---|---|---|---|
| Max WOMAC score
|
All subjects (N=400) | Excluding subjects taking pain medicine (N=304) | Subjects taking pain medicine (N=96) | |||||
| 0 (no pain) | 1 (mild) | 2–4 (mod-ext) | ||||||
| Parapatellar (5 sites) | 0 | 197 | 109 (55) | 50 (25) | 38 (19) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 1–4† | 158 | 60 (58) | 58 (37) | 40 (25) | 1.8 (1.1 to 2.9)* | 1.7 (1.0 to 3.0) | 1.9 (0.6 to 5.6) | |
| 5–10‡ | 45 | 5 (11) | 18 (40) | 22 (49) | 4.9 (2.0 to 12.0)** | 3.9 (1.4 to 10.8)*** | 16.2 (2.1 to 125.0)**** | |
| Peri-ligamentous (2 sites) | 0 | 157 | 80 (51) | 47 (30) | 30 (19) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 1–2† | 119 | 51 (43) | 33 (28) | 35 (29) | 0.9 (0.6 to 1.5) | 1.0 (0.5 to 1.7) | 1.0 (0.3 to 3.0) | |
| 3–4‡ | 124 | 43 (35) | 46 (37) | 35 (28) | 0.6 (0.3 to 1.2) | 0.7 (0.3 to 1.4) | 0.8 (0.2 to 3.6) | |
| Peri-meniscal (2 sites) | 0 | 256 | 122 (48) | 76 (30) | 58 (23) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| 1–2† | 109 | 45 (41) | 36 (33) | 28 (26) | 1.1 (0.7 to 1.8) | 1.1 (0.6 to 2.0) | 0.8 (0.3 to 2.4) | |
| 3–4‡ | 35 | 7 (20) | 14 (40) | 14 (40) | 1.1 (0.5 to 2.7) | 1.0 (0.4 to 2.7) | 1.7 (0.1 to 23.2) | |
Prepatellar subregion = summed synovitis scores in five sites.
Periligamentous subregion = summed synovitis scores in two sites around ACL and PCL.
Perimeniscal subregion = summed synovitis scores in two sites around medial and lateral menisci.
p=0.021;
p=0.0005;
p=0.0098;
p=0.0077.
Mild synovitis as defined by the summed synovitis score at each subregion.
Moderate to severe synovitis as defined by the summed synovitis score at each subregion.
Multi-adjusted model: summed synovitis in three regions adjusting for each other, also adjusting for age, sex, body mass index, radiographic osteoarthritis status, MRI bone marrow lesions and effusions.
ACL, anterior cruciate ligament; ext, extreme; mod, moderate; PCL, posterior cruciate ligament; ref, reference; WOMAC, Western Ontario and McMaster Osteoarthritis Index.