Table 1.
Effect of sensory interventions on lifespan in invertebrate model systems.
| Intervention type | Genes | Direction of change | Reference | Other comments |
|---|---|---|---|---|
| Caenorhabditis elegans | ||||
| Sensory cilia mutants | che-2, che-13, osm-1, osm-5, osm-6, che-3, che-11, daf-19, daf-10, daf-6, mec-8, mec-1, osm-3 | extend | (Apfeld & Kenyon 1999), daf-10 & osm-3 (Maier et al 2010), che-11 (Bialas et al 2009), osm-3 & osm-5 (Lee & Kenyon 2009) |
daf-10 and osm-5 are required by somatic gonad signaling daf-10, daf-19, osm-3 and osm-5 are partially daf-16 dependent |
| mec-1 | no effect | (Apfeld & Kenyon 1999) | weak defect in amphid cilia fasciculation | |
| Amphid sheath cell ablation | extend | (Apfeld & Kenyon 1999) | ||
| Sensory signal mutants | tax-4 | extend | (Apfeld & Kenyon 1999) | tax-4 is daf-16 dependent |
| tax-2 | no effect | (Apfeld & Kenyon 1999) | ||
| Gustatory neurons ablations | ASI, ASG, | extend | (Alcedo & Kenyon 2004) | Full (ASI, ASG) or partial (AWA, AWC) daf-16 and daf-2 dependent |
| ASJ, ASK, ASI/ASJ, ASI/ASK, ADF, | no effect | |||
| Olfactory neurons ablations | AWA, AWA/AWC | extend | (Alcedo & Kenyon 2004) | Partially daf16 dependent |
| ASE, AWC | no effect | |||
| Olfactory mutants | odr-7, odr-2, odr-3, str-2 | extend | (Alcedo & Kenyon 2004) | |
| odr-1, odr-10 | no effect | |||
| G-protein mutants | odr-3, gpa-1, gpa-9, gpc-1, gpa-11 | extend | (Alcedo & Kenyon 2004, Lans et al 2009, Lans & Jansen 2007) | gpa-1, gpa-11, odr-3 and gpc-1 are daf-16 dependent |
| A diffusible bacterial product exposure | shorten | (Smith et al 2008) | The exposure suppresses lifespan extension from DR | |
| Thermosensory neurons (AFD/AIY) neurons (AFD/AIY) | AFD (ablation), ttx-1, ttx-3, tax-2, tax-4 | shorten | (Lee & Kenyon 2009) | At warm temperature (25°C). daf-9 and daf-12 dependent |
| Different food type exposure | nmur-1 | both | (Maier et al) | nmur-1 effect is dependent on the bacterial lipopolysaccharide structure |
| Dauer pheromone exposure | no effect | (Alcedo & Kenyon 2004) | ||
| extend | (Kawano et al 2005) | daf-16 dependent | ||
| TRP channel mutant | ocr-2 | extend | (Lee & Ashrafi 2008) | daf-16 dependent |
| Mutants in ciliary functions | mks-1/mksr-1, mks-1/mksr-2, mksr-1/mksr-2, nph-1, nph-4, ifta-2 | extend | (Bialas et al 2009, Schafer et al 2006, Winkelbauer et al 2005) |
nph-1 and nph-4 are daf-19 dependent ifta-2, mks-1/mksr-1/mksr-2 are part of the daf-2 pathway and depends on daf-16 |
| Drosophila melanogaster | ||||
| Food-derived odor exposure | shorten | (Libert et al 2007, Poon et al 2010) | Gr63a-dependent | |
| Olfactory mutant CO2 sensor mutant Abnormal light/dark period |
Or83b Gr63a |
extend extend shorten |
(Libert et al 2007) (Poon et al 2010) (Pittendrigh & Minis 1972) |
|
| Social cues from conspecifics | extend | (Ruan & Wu 2008) | In short-lived Sod mutant background | |
| Phormia terraenovae | ||||
| Abnormal light/dark period | shorten | (von Saint Paul & Aschoff 1978) | ||
| Apis mellifera | ||||
| Brood pheromone exposure | shorten | (Smedal et al 2009) | ||