Table 2. Interactions by protein function.

Protein	Actual	n	R	N	Expected	Ratio	p-value	z-score
PCBP-1	11	108	13	296	4.743	2.319	0.000402	3.68
Alpha-actinin 4	14	108	19	296	6.932	2.019	0.000754	3.476
HSP60	17	108	27	296	9.851	1.726	0.003122	2.993
14-3-3 beta/alpha	34	108	56	296	20.43	1.664	3.71E-05	4.176
14-3-3 zeta/delta	55	108	97	296	35.39	1.554	5.33E-07	5.035

Interactions by protein function based on the connectivity with the tumor tissue signatures and with proteins from the human proteome MetaCore database. The proteins were considered over-connected when the number of observed interactions exceeded the number of expected interactions. Actual: number of network objects in the signature which interact with the chosen object; n: number of network objects in the signature; R: number of network objects in the background list which interact with the chosen object; N: total number of protein-based objects in the background list; Expected: mean of hypergeometric distribution. Ratio: connectivity ratio (Actual/Expected); z-score: (Actual-Expected)/(standard deviation); p-value: probability to have the value of Actual or higher (lower for negative z-score) by chance under null hypothesis of no over- or under-connectivity.