Table 2.
Familiarity condition |
Novelty condition |
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---|---|---|---|---|---|---|---|---|---|---|
Talairach coordinates |
Talairach coordinates |
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Contrast | Lobe | Region | z | x | y | z | z | x | y | z |
HC > RBD | Anterior | Left culmen | 4.10 | −24 | −30 | −24 | 4.10 | −36 | −42 | −18 |
Midbrain | Left subthalamic nucleus | 3.50 | −10 | −18 | −2 | |||||
Occipital | Left cuneus (BA18) | 3.42 | −18 | −92 | 12 | |||||
Right fusiform gyrus (BA18) | 2.69 | 30 | −88 | −14 | ||||||
Right fusiform gyrus (BA19) | 2.60 | 34 | −70 | −10 | ||||||
Right inferior occipital gyrus (BA17) | 3.44 | 14 | −92 | −6 | 2.96 | 14 | −92 | −6 | ||
Left lingual gyrus (BA17) | 4.15 | −20 | −90 | 0 | 3.23 | −20 | −88 | 0 | ||
Right lingual gyrus (BA17) | 3.30 | 18 | −86 | −2 | 2.60 | 18 | −86 | −2 | ||
Left lingual gyrus (BA18) | 3.69 | −12 | −72 | −6 | 3.34 | −12 | −86 | −8 | ||
Right lingual gyrus (BA18) | 3.21 | 34 | −68 | −4 | 2.45 | 16 | −80 | −6 | ||
Left middle occipital gyrus (BA18) | 4.15 | −18 | −98 | 8 | 3.75 | −18 | −96 | 6 | ||
Right middle occipital gyrus (BA18) | 3.53 | 24 | −84 | 0 | 3.29 | 24 | −82 | 0 | ||
Limbic | Left parahippocampal gyrus (BA36) | 3.81 | −34 | −28 | −22 | |||||
Right posterior cingulate (BA31) | 2.55 | 28 | −60 | 22 | ||||||
Parietal | Right inferior parietal lobule (BA40) | 2.34 | 38 | −52 | 42 | |||||
Right precuneus (BA7) | 3.09 | 16 | −60 | 44 | 3.65 | 30 | −48 | 40 | ||
Right superior parietal lobule (BA7) | 3.44 | 34 | −58 | 54 | ||||||
Posterior | Left declive | 3.90 | −36 | −60 | −14 | |||||
Right declive | 3.32 | 32 | −80 | −16 | ||||||
Sub-lobar | Left lentiform nucleus (putamen) | 3.66 | −16 | 2 | 12 | |||||
Left thalamus | 3.83 | −18 | −30 | 0 | ||||||
Temporal | Left fusiform gyrus (BA37) | 3.74 | −36 | −52 | −12 | 3.38 | −42 | −40 | −14 | |
Right fusiform gyrus (BA37) | 2.92 | 40 | −62 | −8 | ||||||
Left fusiform gyrus (BA20) | 3.53 | −38 | −34 | −18 | ||||||
Left inferior temporal gyrus (BA20) | 3.50 | −60 | −48 | −14 | ||||||
Left inferior temporal gyrus (BA37) | 3.16 | −64 | −50 | −8 | ||||||
Left middle temporal gyrus (BA21) | 3.33 | −66 | −32 | −2 | ||||||
RBD > HC | Frontal | Right inferior frontal gyrus (BA9) | 2.76 | 54 | 6 | 32 | ||||
Left medial frontal gyrus (BA9) | 2.88 | −4 | 48 | 16 | ||||||
Left medial frontal gyrus (BA11) | 3.77 | −6 | 34 | −12 | ||||||
Left medial frontal gyrus (BA10) | 2.54 | −6 | 48 | −4 | ||||||
Right middle frontal gyrus (BA6) | 2.82 | 48 | 2 | 42 | ||||||
Right precentral gyrus (BA6) | 3.69 | 54 | 2 | 36 | 3.12 | 54 | −4 | 32 | ||
Limbic | Left anterior cingulate (BA24) | 3.55 | −2 | 32 | 10 | |||||
Left anterior cingulate (BA32) | 3.00 | −10 | 38 | 12 |
Maps, created through spatial mixture models, were thresholded at z ≥ 2.3 and p < 0.0001. Highlighted rows indicate differences in activation that occurred during both conditions. RBD = remitted bipolar disorder patients; HC = healthy controls; BA = Brodmann area.