TABLE 1.
FXR-regulated genes in metabolism
| Metabolism | Target Gene | Physiologic Function |
|---|---|---|
| Bile acid | CYP7A1 | Bile acid synthesis |
| CYP8B1 | Bile acid synthesis | |
| BSEP | Biliary bile acid secretion | |
| NTCP | Basolateral bile acid uptake | |
| SHP | Bile acid synthesis | |
| OSTα/β | Basolateral bile acid secretion | |
| IBABP | Intracellular bile acid transport | |
| FGF15/19 | Bile acid synthesis | |
| Glucose | PEPCK | Gluconeogenesis |
| G6Pase | Gluconeogenesis | |
| CREB | Gluconeogenesis | |
| FoxO1 | Gluconeogenesis | |
| HNF4α | Gluconeogenesis | |
| FGF15/FGF19 | gluconeogenesis | |
| Insulin | Glucose metabolism | |
| Triglyceride | SREBP-1 | Lipogenesis |
| ChREBP | Lipogenesis | |
| PPARα | Fatty acid oxidation | |
| CES1 | Fatty acid oxidation | |
| FGF21 | Fatty acid oxidation | |
| ApoCII | Triglyceride clearance | |
| ApoCIII | Triglyceride clearance | |
| ApoA5 | Triglyceride clearance | |
| Cholesterol | PCSK9 | LDL uptake |
| SR-BI | HDL uptake | |
| ApoAI | HDL biogenesis | |
| ABCG5/G8 | Cholesterol secretion |
CES1, carboxylesterase 1; CREB, cAMP response element binding protein; FoxO1, forkhead box protein O1; IBABP, intestinal bile acid binding protein.