TABLE 2.
Phosphatidic acid binding proteins
| Protein Name | PtdOH Function | Binding Site | References |
|---|---|---|---|
| Kinases | |||
| Raf1 | Membrane recruitment | AAs 339–423 | Ghosh et al. (1996, 2003), Rizzo et al. (1999, 2000) |
| PKCε | Membrane recruitment | C2 domain | Corbalan-Garcia et al. (2003), Jose Lopez-Andreo et al. (2003) |
| PKCζ | Activation | Unknown | Nakanishi and Exton (1992), Limatola et al. (1994) |
| PKCα | Activation | Unknown | Yokozeki et al. (1998), Nakashima (2002) |
| PKCδ | Activation | Unknown | Aris et al. (1993) |
| mTOR | Activation | FRB domain - R2109 | Fang et al. (2001), Veverka et al. (2008) |
| p70S6K1 | Activation | Unknown | Lehman et al. (2007) |
| PIP5K | Activation | Unknown | Jenkins et al. (1994), Arneson et al. (1999), Roach et al. (2012) |
| Fer | Activation | R417, R425, and H426 | Itoh et al. (2009) |
| GRK | Activation | Unknown | DebBurman et al. (1995) |
| Akt | Membrane recruitment | PH domain | Mahajan et al. (2010), Bruntz et al. (2014) |
| PAK1 | Activation | Unknown | Bokoch et al. (1998) |
| PKN | Activation | Unknown | Khan et al. (1994), Morrice et al. (1994) |
| SPHK1 | Membrane recruitment | C terminus | Jose Lopez-Andreo et al. (2003) |
| Phosphatases | |||
| SHP1 | Activation | C terminus - last 41 AAs | Tomic et al. (1995), Frank et al. (1999) |
| PP1cγ | Inhibition | AAs 274–299 | Jones and Hannun (2002), Jones et al. (2013) |
| Lipin1β | Membrane localization | Polybasic region around AA 153 | Corbalan-Garcia et al. (2003), Jose Lopez-Andreo et al. (2003) |
| G protein regulators | |||
| Rac-GDI | Inhibition | Unknown | Chuang et al. (1993) |
| n-Chimaerin | Activation | Unknown | Ahmed et al. (1993) |
| NF1 | Inhibition | Unknown | Bollag and McCormick (1991) |
| ASAP1 | Activation | Unknown | Randazzo (1997), Brown et al. (1998b) |
| AGAP1 | Activation | Unknown | Nie et al. (2002) |
| ACAP1/2 | Activation | Unknown | Jackson et al. (2000) |
| ArfGAP1/2 | Activation | Unknown | Randazzo (1997) |
| RA-RhoGAP | Activation | R399 | Kurooka et al. (2011) |
| RSS4 | Inhibition | First 57 AAs | Ouyang et al. (2003) |
| SOS | Membrane recruitment | R475 and R479 | Zhao et al. (2007) |
| DOCK2 | Membrane recruitment | C terminus | Nishikimi et al. (2009) |
| Phosphodiesterases | |||
| PDE4D3 | Activation | AAs 31–59 | Némoz et al. (1997), Grange et al. (2000) |
| PDE4B1 | Activation | Unknown | Némoz et al. (1997) |
| PDE4A5 | Activation | Unknown | Bawab et al. (1997), Némoz et al. (1997) |
| PDE4A1 | Membrane recruitment | W19 and W20 | Baillie et al. (2002) |
| Phospholipase C | |||
| PLCβ1 | Activation | Y952, 1955 | Litosch (2003) |
| PLCγ1 | Activation | Unknown | Jones and Carpenter (1993) |
| PLCε | Activation | Unknown | Murthy et al. (2013) |
| PLCδ3 | Activation | Unknown | Pawelczyk and Matecki (1999) |
| Miscellaneous | |||
| NADPH oxidase | Activation | R70, K55 in p47phox | McPhail et al. (1995, 1999), Palicz et al. (2001), Karathanassis et al. (2002) |
| Ng | Membrane recruitment | Unknown | Baudier et al. (1991) |
| β-Cotomer | Unknown | Unknown | Manifava et al. (2001) |
| Af1/6 | Unknown | Unknown | Manifava et al. (2001) |
| NSF | Unknown | Unknown | Manifava et al. (2001) |
| Kinesin | Unknown | Unknown | Manifava et al. (2001) |
| Sin1 | Membrane localization | PH domain | Schroder et al. (2007) |
| ANT | Unknown | Unknown | Epand et al. (2009) |
| Rac1 | Membrane recruitment | C-terminal polybasic motif | Chae et al. (2008) |
AA, amino acid; ACAP, ArfGAP with coiled-coil, ankyrin repeat, and PH domains; ANT, adenine nucleotide translocase.