Table III.

Oligodendrocyte dysfunction in SUDs and depression.^*

SUDs	Depression
Enhanced programmed cell death/apoptosis (AUDs)	Decreased cell density
Decreased expression of myelin-related genes, e.g., MBP, PLP-1	Decreased expression of myelin-related genes, e.g., MBP, MOG, PLP-1
Decreased immediate-early gene expression, e.g c-Fos	Decreased RNA binding protein expression
	Increased activation after ECT/ECS

SUDs, substance use disorders; MBP, myelin basic protein, PLP-1, phospholipid protein-1; MOG, myelin-oligodendrocyte glycoprotein; RNA, ribonucleic acid; ECT, electroconvulsive therapy; ECS, electroconvulsive seizure.

^*Italicised text denotes potential convergent mechanisms in SUDs and depressive disorders.