Table 2.
Ubiquitin/proteasome system and GHK.
| Up | Gene title | Percent change in gene expression |
|---|---|---|
| 1 | Ubiquitin specific peptidase 29, USP29 | 1056 |
| 2 | Ubiquitin protein ligase E3 component n-recognin 2, UBR2 | 455 |
| 3 | Gamma-aminobutyric acid (GABA) B receptor, 1 /// ubiquitin D, GABBR1 /// UBD | 310 |
| 4 | Ubiquitin specific peptidase 34, USP34 | 195 |
| 5 | Parkinson protein 2, E3 ubiquitin protein ligase (parkin), PARK2 | 169 |
| 6 | Ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast), UBE2I | 150 |
| 7 | Ubiquitin protein ligase E3 component n-recognin 4, UBR4 | 146 |
| 8 | Ubiquitin protein ligase E3B, UBE3B | 116 |
| 9 | Ubiquitin specific peptidase 2, USP2 | 104 |
| 10 | Ubiquitin-like modifier activating enzyme 6, UBA6 | 104 |
| 11 | Ubiquitination factor E4B (UFD2 homolog, yeast), UBE4B | 97 |
| 12 | Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), UBE2M | 92 |
| 13 | Ubiquitin-like modifier activating enzyme 7, UBA7 | 88 |
| 14 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1, HECW1 | 81 |
| 15 | Proteasome (prosome, macropain) 26S subunit, ATPase, 3, PSMC3 | 81 |
| 16 | Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast), UBE2D1 | 79 |
| 17 | Proteasome (prosome, macropain) subunit, beta type, 2, PSMB2 | 79 |
| 18 | Ubiquitin protein ligase E3 component n-recognin 5, UBR5 | 77 |
| 19 | Ubiquitin specific peptidase 21, USP21 | 76 |
| 20 | OTU domain, ubiquitin aldehyde binding 2, OTUB2 | 76 |
| 21 | Proteasome (prosome, macropain) inhibitor subunit 1 (PI31), PSMF1 | 75 |
| 22 | Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast), UBE2H | 73 |
| 23 | Ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast), UBE2N | 72 |
| 24 | Ubiquitin carboxyl-terminal hydrolase L5, UCHL5 | 71 |
| 25 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13, PSMD13 | 70 |
| 26 | Ubiquitin associated protein 1, UBAP1 | 70 |
| 27 | Ubiquitin-conjugating enzyme E2B (RAD6 homolog), UBE2B | 69 |
| 28 | TMEM189-UBE2V1 readthrough /// ubiquitin-conjugating enzyme E2 variant 1, TMEM189-UBE2V1 /// UBE2V1 | 67 |
| 29 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1, PSMD1 | 64 |
| 30 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3, PSMD3 | 64 |
| 31 | Ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (drosophila), ARIH1 | 61 |
| 32 | BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), BAP1 | 60 |
| 33 | Ubiquitin interaction motif containing 1, UIMC1 | 60 |
| 34 | Ubiquitin associated protein 2-like, UBAP2L | 57 |
| 35 | Ubiquitin protein ligase E3 component n-recognin 7 (putative), UBR7 | 56 |
| 36 | Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast), UBE2G1 | 54 |
| 37 | Itchy E3 ubiquitin protein ligase homolog (mouse), ITCH | 54 |
| 38 | Ubiquitin-conjugating enzyme E2D 4 (putative), UBE2D4 | 51 |
| 39 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10, PSMD10 | 50 |
| 40 | WW domain containing E3 ubiquitin protein ligase 1, WWP1 | 50 |
| 41 | Ubiquitin-like 3, UBL3 | 50 |
|
| ||
| Down | Gene title | Percent change in gene expression |
|
| ||
| 1 | Ubiquitin associated and SH3 domain containing A, UBASH3A | −89 |