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. 1995 May 23;92(11):4848–4852. doi: 10.1073/pnas.92.11.4848

Surfactant protein a promotes attachment of Mycobacterium tuberculosis to alveolar macrophages during infection with human immunodeficiency virus.

J F Downing 1, R Pasula 1, J R Wright 1, H L Twigg 3rd 1, W J Martin 2nd 1
PMCID: PMC41804  PMID: 7761411

Abstract

The incidence of tuberculosis is increasing on a global scale, in part due to its strong association with human immunodeficiency virus (HIV) infection. Attachment of Mycobacterium tuberculosis to its host cell, the alveolar macrophage (AM), is an important early step in the pathogenesis of infection. Bronchoalveolar lavage of HIV-infected individuals demonstrated the presence of a factor which significantly enhances the attachment of tubercle bacilli to AMs 3-fold relative to a normal control population. This factor is surfactant protein A (SP-A). SP-A levels are increased in the lungs of HIV-infected individuals. SP-A levels and attachment of M. tuberculosis to AMs inversely correlate with peripheral blood CD4 lymphocyte counts. Elevated concentrations of SP-A during the progression of HIV infection may represent an important nonimmune risk factor for acquiring tuberculosis, even before significant depletion of CD4 lymphocytes in the peripheral blood occurs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abou-Zeid C., Garbe T., Lathigra R., Wiker H. G., Harboe M., Rook G. A., Young D. B. Genetic and immunological analysis of Mycobacterium tuberculosis fibronectin-binding proteins. Infect Immun. 1991 Aug;59(8):2712–2718. doi: 10.1128/iai.59.8.2712-2718.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barnes P. F., Bloch A. B., Davidson P. T., Snider D. E., Jr Tuberculosis in patients with human immunodeficiency virus infection. N Engl J Med. 1991 Jun 6;324(23):1644–1650. doi: 10.1056/NEJM199106063242307. [DOI] [PubMed] [Google Scholar]
  3. Bobak D. A., Gaither T. A., Frank M. M., Tenner A. J. Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages. J Immunol. 1987 Feb 15;138(4):1150–1156. [PubMed] [Google Scholar]
  4. Daley C. L., Small P. M., Schecter G. F., Schoolnik G. K., McAdam R. A., Jacobs W. R., Jr, Hopewell P. C. An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus. An analysis using restriction-fragment-length polymorphisms. N Engl J Med. 1992 Jan 23;326(4):231–235. doi: 10.1056/NEJM199201233260404. [DOI] [PubMed] [Google Scholar]
  5. Di Perri G., Cruciani M., Danzi M. C., Luzzati R., De Checchi G., Malena M., Pizzighella S., Mazzi R., Solbiati M., Concia E. Nosocomial epidemic of active tuberculosis among HIV-infected patients. Lancet. 1989 Dec 23;2(8678-8679):1502–1504. [PubMed] [Google Scholar]
  6. Dolin P. J., Raviglione M. C., Kochi A. Global tuberculosis incidence and mortality during 1990-2000. Bull World Health Organ. 1994;72(2):213–220. [PMC free article] [PubMed] [Google Scholar]
  7. Drickamer K., Dordal M. S., Reynolds L. Mannose-binding proteins isolated from rat liver contain carbohydrate-recognition domains linked to collagenous tails. Complete primary structures and homology with pulmonary surfactant apoprotein. J Biol Chem. 1986 May 25;261(15):6878–6887. [PubMed] [Google Scholar]
  8. Haagsman H. P. Surfactant proteins A and D. Biochem Soc Trans. 1994 Feb;22(1):100–106. doi: 10.1042/bst0220100. [DOI] [PubMed] [Google Scholar]
  9. Harries A. D. Tuberculosis and human immunodeficiency virus infection in developing countries. Lancet. 1990 Feb 17;335(8686):387–390. doi: 10.1016/0140-6736(90)90216-r. [DOI] [PubMed] [Google Scholar]
  10. Kuhlman M., Joiner K., Ezekowitz R. A. The human mannose-binding protein functions as an opsonin. J Exp Med. 1989 May 1;169(5):1733–1745. doi: 10.1084/jem.169.5.1733. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Perronne C., Ghoubontni A., Leport C., Salmon-Céron D., Bricaire F., Vildé J. L. Should pulmonary tuberculosis be an AIDS-defining diagnosis in patients infected with HIV? Tuber Lung Dis. 1992 Feb;73(1):39–44. doi: 10.1016/0962-8479(92)90078-X. [DOI] [PubMed] [Google Scholar]
  12. Phelps D. S., Rose R. M. Increased recovery of surfactant protein A in AIDS-related pneumonia. Am Rev Respir Dis. 1991 May;143(5 Pt 1):1072–1075. doi: 10.1164/ajrccm/143.5_Pt_1.1072. [DOI] [PubMed] [Google Scholar]
  13. Pottratz S. T., Paulsrud J., Smith J. S., Martin W. J., 2nd Pneumocystis carinii attachment to cultured lung cells by pneumocystis gp 120, a fibronectin binding protein. J Clin Invest. 1991 Aug;88(2):403–407. doi: 10.1172/JCI115318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rieder H. L., Cauthen G. M., Kelly G. D., Bloch A. B., Snider D. E., Jr Tuberculosis in the United States. JAMA. 1989 Jul 21;262(3):385–389. [PubMed] [Google Scholar]
  15. Schlesinger L. S., Bellinger-Kawahara C. G., Payne N. R., Horwitz M. A. Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3. J Immunol. 1990 Apr 1;144(7):2771–2780. [PubMed] [Google Scholar]
  16. Selwyn P. A., Hartel D., Lewis V. A., Schoenbaum E. E., Vermund S. H., Klein R. S., Walker A. T., Friedland G. H. A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection. N Engl J Med. 1989 Mar 2;320(9):545–550. doi: 10.1056/NEJM198903023200901. [DOI] [PubMed] [Google Scholar]
  17. Small P. M., Shafer R. W., Hopewell P. C., Singh S. P., Murphy M. J., Desmond E., Sierra M. F., Schoolnik G. K. Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection. N Engl J Med. 1993 Apr 22;328(16):1137–1144. doi: 10.1056/NEJM199304223281601. [DOI] [PubMed] [Google Scholar]
  18. Snider D. E., Jr The relationship between tuberculosis and silicosis. Am Rev Respir Dis. 1978 Sep;118(3):455–460. doi: 10.1164/arrd.1978.118.3.455. [DOI] [PubMed] [Google Scholar]
  19. Tenner A. J., Robinson S. L., Borchelt J., Wright J. R. Human pulmonary surfactant protein (SP-A), a protein structurally homologous to C1q, can enhance FcR- and CR1-mediated phagocytosis. J Biol Chem. 1989 Aug 15;264(23):13923–13928. [PubMed] [Google Scholar]
  20. Voss T., Eistetter H., Schäfer K. P., Engel J. Macromolecular organization of natural and recombinant lung surfactant protein SP 28-36. Structural homology with the complement factor C1q. J Mol Biol. 1988 May 5;201(1):219–227. doi: 10.1016/0022-2836(88)90448-2. [DOI] [PubMed] [Google Scholar]
  21. Wright J. R., Hawgood S. Pulmonary surfactant metabolism. Clin Chest Med. 1989 Mar;10(1):83–93. [PubMed] [Google Scholar]
  22. Wright J. R., Wager R. E., Hawgood S., Dobbs L., Clements J. A. Surfactant apoprotein Mr = 26,000-36,000 enhances uptake of liposomes by type II cells. J Biol Chem. 1987 Feb 25;262(6):2888–2894. [PubMed] [Google Scholar]
  23. Wright J. R., Youmans D. C. Pulmonary surfactant protein A stimulates chemotaxis of alveolar macrophage. Am J Physiol. 1993 Apr;264(4 Pt 1):L338–L344. doi: 10.1152/ajplung.1993.264.4.L338. [DOI] [PubMed] [Google Scholar]
  24. Zimmerman P. E., Voelker D. R., McCormack F. X., Paulsrud J. R., Martin W. J., 2nd 120-kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A. J Clin Invest. 1992 Jan;89(1):143–149. doi: 10.1172/JCI115554. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. van Iwaarden J. F., van Strijp J. A., Ebskamp M. J., Welmers A. C., Verhoef J., van Golde L. M. Surfactant protein A is opsonin in phagocytosis of herpes simplex virus type 1 by rat alveolar macrophages. Am J Physiol. 1991 Aug;261(2 Pt 1):L204–L209. doi: 10.1152/ajplung.1991.261.2.L204. [DOI] [PubMed] [Google Scholar]

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