Figure 5.

Reduced $\mathrm{\Delta }{\left[C{a}^{2+}\right]}_{ER}^{(i)}$ and unaltered ER Ca ²⁺ permeability in db/db beta-cells. (A) Average BHQ-triggered [Ca²⁺]_i transients in Ca²⁺-free and Na⁺-free solutions from normal beta-cells (n = 43, dark) and db/db diabetic beta-cells (n = 31, red). (B) Time courses of average J _release in normal and db/db cells. (C) Reduced initial $\mathrm{\Delta }{\left[C{a}^{2+}\right]}_{ER}^{(i)}$ in db/db diabetic beta-cells relative to normal cells (P < 0.05). (D) The average relative ER permeability during the BHQ stimulation was approximately the same in normal and db/db diabetic beta-cells