Fig. 1.

Dose-responsed motor function curve and abnormal involuntary movement (AIM) scoring relating l-dopa dosage with or without acupuncture. (A) Different doses of l-dopa (0, 5, 10, 15, and 20 mg/kg) were administered to the mice with and without acupuncture treatment. The dashed line indicates half the behavioural effect elicited by maximal dose of l-dopa (20 mg/kg). The curve of the group treated with l-dopa and acupuncture combination was shifted to the left compared to the group treated only with l-dopa. The dose that had the same behavioural effect of l-dopa was lower in the curve of the group receiving the combination treatment. Data are presented as the mean±SEM. (B) Ten days after the l-dopa injection, AIM scoring tests were given to all mice. There was a significant difference between mice treated only with high dose of l-dopa (20 mg/kg) and those treated with l-dopa+AP combination. ^††p<0.01, compared to group of l-dopa (20 mg/kg) only, analysed by a repeated-measures two-way ANOVA and Bonferroni’s post hoc test.