Skip to main content
. Author manuscript; available in PMC: 2014 Oct 2.
Published in final edited form as: Brain Res. 2013 Dec 7;1544:33–44. doi: 10.1016/j.brainres.2013.11.028

Fig. 3.

Fig. 3

Effect of Levodopa-induced dyskinesia (LID) and acupuncture treatment on abnormal FosB activation in the striatum. (A) Western blotting analysis for markers of FosB in striatum. “contra” refers to contralateral (un-lesioned) side and “ipsi” refers to ipsilateral (lesioned) side striatum of each group. (B and C) Immunofluorescence image for the mice striatum. The mice striatum were double stained for tyrosine hydroxylase (TH) and FosB and then DAPI stained for nuclei at low magnification (B) and high magnification (C). (B) Low magnification image of the striatum of l-dopa (15 mg/kg) only group (scale bars indicate 400 µm). (C) High magnification image of the striatum of 6-OHDA, l-dopa (15 mg/kg) only, and l-dopa (15 mg/kg)+AP group (scale bars indicate 100 µm). FosB activations showed not only un-colocalisation with TH but also overactivation where dopamine fibres were depleted, which means that this protein activation was not affected by presynaptic TH protein and postsynaptic neuronal activation. **p<0.05 compared to the value of control group, #p<0.05 compared to the value of 6-OHDA group, and †p<0.05 compared to the value of l-dopa (15 mg/kg) only group, analysed by a one-way ANOVA, followed by Bonferroni’s post hoc test. Data are presented as the mean±SEM.