Table 1.
Ionizing Radiation-Responsive miRNAs and Their Targets in Various Cell Lines
| miRNA | Response | Cell type | Target | Biological effects | Reference |
|---|---|---|---|---|---|
| *let-7 | Increase/decrease | Primary and cancer | K-Ras, CDC25a, CDK6 | Overcome the radioresistance of cancer cells and improve radiotherapeutic effects Represses cell proliferation |
Johnson et al. (2007), Weidhaas et al. (2007), Cha et al. (2009a), Chaudhry et al. (2010b), Oh et al. (2010) |
| miR-7 | Decrease | Primary and cancer | EGFR, IGFR, PIK3CD, PAK1 LSH |
Increase radiosensitivity of human cancer Repress tumorigenesis and revers the metastasis process of cancer cells |
Ishii and Saito (2006), Ilnytskyy et al. (2008), Lee et al. (2011), Zhao et al. (2013) |
| miR-15a/16 | Increase | Primary and cancer | Bcl-2, CDC25a, Cyclin E1/D1, Wip1, HuR, VEGF |
Induce cancer cells apoptosis Control cell cycle Inhibit cancer stem cells proliferation and growth |
Chaudhry (2009), Chaudhry et al. (2010b), Zhang et al. (2010c), Sun et al. (2013) |
| miR-17-92 | Increase | Cancer | P21, CTGF, E2F, PTEN, Bim, TGFBR2 | Enhance radioresistance of lymphoma cells | Jiang et al. (2010), Metheetrairut and Slack (2013) |
| miR-18a | Increase/decrease | Primary and cancer | ATM | Affect DNA damage repair ability | Maes et al. (2008), Chaudhry (2009), Chaudhry et al. (2010a), Wagner-Ecker et al. (2010), Song et al. (2011) |
| *miR-21 | Increase | Primary and cancer | PTEN, ERK, EGFR, CDC25a, PDCD4, Big-h3 | Modulate radioresistance or radiosensitivity Induce tumor angiogenesis and metastasis |
Zhang et al. (2010b), Zhou et al. (2010), Liu et al. (2011a) |
| miR-24 | Increase/decrease | Primary and cancer | H2AX, E2F2, Myc | Affect DNA repair ability | Lal et al. (2009a, 2009b), Metheetrairut and Slack (2013) |
| miR-26b | Increase/decrease | Primary and cancer | ATF2, GATA4, COX-2, PTGS2, ATM, PTEN | Enhance the effect of IR Affect DNA damage repair ability |
Simone et al. (2009), Ji et al. (2010), Arora et al. (2011), Dickey et al. (2011), Han et al. (2012), Lin et al. (2012), Palumbo et al. (2012), Li et al. (2013) |
| *miR-34s | Increase | Primary and cancer | E2F, SIRT1, CDK4, Myc, HDAC1, NOTCH, Bcl-2 | Enhance radiosensitivity Induce apoptosis |
Hermeking (2009), Liu et al. (2011b), Balca-Silva et al. (2012), Duan et al. (2013), Metheetrairut and Slack (2013) |
| miR-99a | Increase/decrease | Primary and cancer | SNF2H, FGFR3, Akt | Influence the processes of NHEJ and HR in DNA damage repair | Mueller et al. (2012), Chakrabarti et al. (2013), Metheetrairut and Slack (2013) |
| miR-100 | Increase/decrease | Primary and cancer | ATM, DNA-PKcs, PLK1 | Modulate radiosensitivity | Ng et al. (2010), Liu et al. (2012a), Metheetrairut and Slack (2013) |
| miR-101 | Increase | Primary | DNA-PKcs, ATM | Enhance radiosensitivity of cancer cells | Yan et al. (2010), Chen et al. (2011), Templin et al. (2011b) |
| miR-106 | Increase/decrease | Primary and cancer | p21, E2F5 | Promote cell cycling | Cha et al. (2009a), Dickey et al. (2011), Li et al. (2011), Gu and Zhang (2013), Metheetrairut and Slack (2013) |
| miR-143/145 | Increase/decrease | Primary and cancer | Myc, K-Ras, FHIT, Bcl-2 | Modulate radiosensitivity of cancer cells Promote apoptosis |
Josson et al. (2008), Chaudhry et al. (2010b), Lin et al. (2011), Kent et al. (2012), Liu et al. (2012b), Metheetrairut and Slack (2013) |
| *miR-181a | Decrease | Primary | ATM, K-Ras, Bcl-2 | Affect DNA repair and promote tumor cells apoptosis | Ishii and Saito (2006), Chen et al. (2010), Wang et al. (2010), Shin et al. (2011), Chaudhry et al. (2013) |
| miR-185 | decrease | Cancer | ATR, Six1 | Inhibit cancer cells proliferation and enhance radiation-induced apoptosis | Imam et al. (2010), Wang et al. (2013) |
| miR-210 | Increase/decrease | Primary and cancer | RAD52, HIF | A component of radioresistance and promote a more efficient DSB repair | Marsit et al. (2006), Yang et al. (2012), Barjaktarovic et al. (2013), Grosso et al. (2013) |
| miR-221/222 | Increase/decrease | Primary and cancer cell | p27, PTEN, PUMA | Regulate cancer cell proliferation and radioresistance | Chun-Zhi et al. (2010), Zhang et al. (2010a), Metheetrairut and Slack (2013) |
| miR-335 | Decrease | Cancer | CtIP, Rb1 | Involve in the processes of HR in the DNA damage repair | Shi et al. (2012), Martin et al. (2013) |
| miR-421 | Decrease | Cancer | ATM | Affect DNA damage repair | Hu et al. (2010) |
| *miR-449a | Increase | Cancer | HDAC1, NOTCH1, Bcl-2, CyclinD1 | Enhance radiosensitivity Induce apoptosis |
Josson et al. (2008), Noonan et al. (2009), Marcet et al. (2011), Hu et al. (2014) |
| miR-521 | Decrease | Cancer | CSA | Affect DNA damage repair and modulate radiosensitivity of prostate cancer cells | Josson et al. (2008) |
| miR-663 | Increase/decrease | Primary and cancer | SMAD3, p21 | Promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma | Maes et al. (2008), Cha et al. (2009b), Yi et al. (2012) |
*
Of special interest.
ATM, ataxia-telangiectasia mutated; IR, ionizing radiation.