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. 2014 Sep 18;14:675. doi: 10.1186/1471-2407-14-675

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© McGoldrick et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Multiple low-dose treatments with S-NPAA significantly reduced tumorigenic cell viability. A) Non-tumorigenic (RWPE-1) and tumorigenic prostate cells (LNCaP, DU145 and PC-3) were treated with the indicated doses of S-NPAA at 0 hours and given additional doses at 6, 12, 24, and 36 hours. Cell viability was measured as a percent of control at 48 hours using a MTS viability assay. Data points marked with letters that are not the same are significantly different at p < 0.05. B) Non-tumorigenic and tumorigenic prostate cells were treated with a 15 μM dose of S-NPAA at 0 hours and given additional 15 μM doses at 6, 12, 24, and 36 hours. Cell viability was measured at the indicated time point as a percent of control using a MTS viability assay; *indicates a significant difference between tumorigenic cells and RWPE-1 at p < 0.05.