Table 1.
The clinical presentations and pathological features of three intraductal neoplasms of pancreas
| Gastric- type IPMN | ITA | ITPN | |
|---|---|---|---|
| Gender (M/F) | 10/6 | 5/2 | 2/4 |
| Age (average age) | 39-78 (61) | 47-74 (58) | 48-70 (64) |
| Site (head/body/tail) | 10/3/3 | 4/3/0 | 4/1/1 |
| Clinical features | |||
| Symptoms※ | 8/5/3 | 4/2/1 (back pain) | 4/1/1 (jaundice) |
| Chronic pancreatitis | 5/16 | 4/7 | 2/6 |
| Diabetes mellitus | 4/16 | 1/7 | 3/6 |
| Chronic use of tobacco | 6/16 | 3/7 | 2/6 |
| CA-199 elevated in blood | 5/16 | 1/7 | 2/6 |
| CEA elevated in blood | 2/16 | 0/7 | 0/6 |
| Pathological features | |||
| Diameter | 1-6 cm | 0.6-3 cm | 1.5-4.5 cm |
| Microscopic features | Papillary growth with large mucin | Tubulopapillary growth with mucin | Tubulopapillary growth without luminal mucin |
| Immunohistochemistry | |||
| MUC5AC | 16/16 | 7/7 | 3/6 |
| MUC1 | 0/16 | 0/7 | 3/6 |
| MUC2 | 9/16 (goblet cells) | 3/7 (goblet cells) | 0 |
| Ki-67 index | <1% | 2/7 3-5% | >20% |
| P53 | - | - | 3/6 |
| KRAS mutation | 9/16 (56%) | 4/7 (57%) | 2/6 (33%) |
※From left to right: abdominal discomfort/routine checkup/other symptoms, such as jaundice, back pain, et al.