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. Author manuscript; available in PMC: 2014 Oct 2.
Published in final edited form as: Biomol Concepts. 2013 Mar 26;4(3):233–257. doi: 10.1515/bmc-2012-0042

Figure 2.

Figure 2

Receptors of HSPGs. Prominent interactions in the CNS that are mediated by HSPGs are shown. Robo receptors bind to Slit ligands, UNC-5 and DCC (deleted in colorectal cencer) receptors bind to Netrin, FGF binds to FGFR and ephrin receptors (Eph) bind to ephrin ligands. Box contains the definition for conserved protein domains. Ig: immunoglobulin; EGF, epidermal growth factor; FN3, fibronectin type III domain; TK, tyrosine kinase domain. [The figure has been modified from the review by Lee et al. (3)]