Table 3. Metabolite Levels.

	Left thalamus			ACC			Left thalamus			ACC
	Control N=55	UHR N=75	P*	Control N=55	UHR N=75	P*	UHR-R N=22	UHR-NR N=29	P**	UHR-R N=22	UHR-NR N=29	P**
Baseline
Glutamate	7.6±1.5	7.0±1.4	0.03	13.2±2.3	13.1±2.8	0.97	7.7±1.3	6.6±1.3	0.003	13.0±2.8	13.4±3.1	0.36
Glx	9.3±2.4	8.8±2.0	0.20	18.0±4.1	18.1±5.6	0.98	9.7+2.1	8.1±1.9	0.01	17.6±5.9	18.8±6.1	0.27
NAA	12.4±0.9	12.1±1.2	0.10	13.0±2.1	12.9±2.0	0.80	12.2±1.8	12.1±0.8	0.65	12.6±2.2	13.2±2.0	0.14
Cr	7.2±0.8	6.9±0.8	0.11	10.1±1.7	10.0±1.7	0.91	7.2±1.1	6.9±0.7	0.33	9.8±2.2	10.2±1.6	0.23
mI	4.9±2.1	4.6±1.5	0.28	8.4±1.4	8.2±1.7	0.45	4.3±1.1	4.4±1.3	0.88	7.9±2.0	8.5±1.7	0.13
TCho	2.1±0.2	1.9±0.3	0.01	2.8±0.7	2.6±0.5	0.24	2.0±0.3	1.9±0.2	0.03	2.6±0.7	2.7±0.5	0.29
	Left thalamus			ACC			Left thalamus			ACC
	Control N=33	UHR N=47	P***	Control N=33	UHR N=47	P***	UHR-R N=22	UHR-NR N=26	P***	UHR-R N=21	UHR-NR N=26	P***
Follow-up
Glutamate	7.1±1.7	6.9±1.4	0.49	13.2±2.4	12.0±2.3	0.13	6.8±1.4	7.1±1.4	0.07	11.8±2.4	12.1±2.4	0.52
Glx	8.7±2.3	8.5±2.1	0.26	17.8±3.7	16.4±3.5	0.56	8.8±2.6	8.2±1.5	0.02	16.5±3.7	16.4±3.4	0.56
NAA	11.6±1.6	11.8±1.1	0.09	13.0±1.5	12.4±1.5	0.14	11.6±1.3	12.0±0.9	0.48	12.2±1.3	12.6±1.6	0.21
Cr	6.9±0.6	6.9±6.2	0.99	9.6±1.4	9.7±1.4	0.38	6.9±0.6	6.9±0.6	0.58	9.3±1.5	10.0±1.3	0.13
mI	4.2±0.9	4.2±0.8	0.07	8.7±2.2	8.0±1.6	0.27	4.1±0.8	4.2±0.9	0.67	7.7±1.6	8.3±1.6	0.10
TCho	1.9±0.2	1.9±0.2	0.17	2.6±0.6	2.5±0.5	0.09	1.9±0.2	1.9±0.2	0.11	2.5±0.5	2.6±0.5	0.63

Abbreviations: ACC, anterior cingulate cortex; Cr, creatine; mI, myo-Inositol; NAA, N-acetyl aspartate; TCho, total choline; UHR-R, ultra high risk - remission; UHR-NR, ultra high risk - non remission. P*, P-value determined by independent samples t-test; P**, P-value determined by binary logistic regression; P***, P-value relating to main effect of group on follow-up metabolite level determined using linear mixed models.