Table 1. Distribution of 24 narcolepsy cases according to exposure status and patients’ characteristics.
Patient’s characteristics Mean ± SD/median/range | All cases (n = 24) | Not vaccinated or vaccinated after disease onset (n = 16) | Vaccinated before disease onset (n = 8) | p value* |
Age (years) | 24.0±14.3 | 26.1±13.1 | 19.9±16.6 | 0.20 |
18.1 | 28.2 | 13.7 | ||
6–55 | 8–55 | 6–50 | ||
Age group | ||||
<20 years of age | 13 (54%) | 7 (44%) | 6 (75%) | 0.21 |
≥20 years of age | 11 (46%) | 9 (56%) | 2 (25%) | |
Male proportion | 12 (50%) | 10 (62.5%) | 2 (25%) | 0.19 |
Cases with cataplexy | 16 (67%) | 10 (63%) | 6 (75%) | 0.67 |
Cases with hypnagogic hallucinations | 14/23 (61%) | 9 (56%) | 5/7 (71%) | 0.66 |
Cases with sleep paralysis | 10 (42%) | 7 (44%) | 3 (38%) | 1.00 |
Cases with all signs and symptoms | 5 (21%) | 3 (19%) | 2 (25%) | 1.00 |
Diagnostic certainty | ||||
Brighton level 1 | 4 (17%) | 2 (12.5%) | 2 (25%) | 0.73 |
Brighton level 2 | 12 (50%) | 8 (50%) | 4 (50%) | |
Brighton level 3 | 8 (33%) | 6 (38%) | 2 (25%) | |
HLA DQB1*0602 positive | 19/24 (79%) | 12/16 (75%) | 7/8 (88%) | 0.63 |
Interval between onset first sleep | 53.3±93.1 | 72.3±116.9 | 24.8±27.5 | 1.00 |
symptoms and onset of cataplexy (days) | 21 | 0 | 23 | |
0–330 | 0–330 | 0–91 | ||
Interval between disease onset and first | 149.1±187.8 | 190.9±218.9 | 65.5±35.7 | 0.42 |
medical visit (days) | 70.5 | 77.5 | 52.5 | |
3–799 | 3–799 | 32–124 | ||
Interval between disease onset and | 427.8±244.52 | 482.1±239.3 | 319.3±231.4 | 0.15 |
confirmatory laboratory investigations | 414 | 422 | 246 | |
(days) | 79–903 | 170–903 | 79–756 |
*Fisher exact test for proportions and Wilcoxon rank test for medians.