Table 3. Risk of narcolepsy ± narcolepsy associated with A/H1N1 (2009) vaccination using the ‘self-controlled case-series method’ according to age and diagnostic classification, in the province of Quebec, 2009–2010.
Observation period | Post-vaccinationrisk period | Post-vaccinationbuffer period | Brighton level | No of casesin analysis | Relative risk | 95% confidenceinterval | Attributable risk per million doses (95% confidence intervals) |
All ages | |||||||
6 months (183 days) beforevaccination to 6 monthsafter vaccination | 16 weeks (112 days) | Weeks 17–24(days 113–168) | 1–3 | 13 | 2.07 | 0.70 to 6.17 | 0.82 [−068 to 1.32] |
1–2 | 9 | 3.55 | 0.89 to 14.21 | 0.97 [−0.17 to 1.26] | |||
No buffer | 1–3 | 13 | 2.66 | 0.89 to 7.90 | 0.99 [−0.19 to 1.38] | ||
1–2 | 9 | 4.55 | 1.14 to 18.21 | 1.06 [0.17 to 1.28] | |||
Persons 6 months to <20 years of age | |||||||
6 months (183 days) beforevaccination to 6 monthsafter vaccination | 16 weeks (112 days) | Weeks 17–24(days 113–168) | 1–3 | 8 | 2.96 | 0.71 to 12.39 | 2.98 [−1.84 to 4.14] |
1–2 | 5 | 7.10 | 0.79 to 63.59 | 3.09 [−0.96 to 3.54] | |||
No buffer | 1–3 | 8 | 3.79 | 0.90 to 15.89 | 3.31 [−0.50 to 4.22] | ||
1–2 | 5 | 9.11 | 1.02 to 81.48 | 3.21 [0.07 to 3.56] | |||
Persons ≥20 years of age | |||||||
6 months (183 days) beforevaccination to 6 monthsafter vaccination | 16 weeks (112 days) | Weeks 17–24(days 113–168) | 1–3 | 5 | 1.18 | 1.19 to 7.09 | 0.09 [−2.58 to 0.52] |
1–2 | 4 | 1.78 | 0.25 to 12.61 | 0.26 [−1.81 to 0.56] | |||
No buffer | 1–3 | 5 | 1.52 | 0.25 to 9.08 | 0.21 [−1.81 to 0.54] | ||
1–2 | 4 | 2.27 | 0.32 to 16.16 | 0.34 [−1.28 to 0.57] |