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. 2014 Sep 29;9(9):e108489. doi: 10.1371/journal.pone.0108489

Table 3. Risk of narcolepsy ± narcolepsy associated with A/H1N1 (2009) vaccination using the ‘self-controlled case-series method’ according to age and diagnostic classification, in the province of Quebec, 2009–2010.

Observation period Post-vaccinationrisk period Post-vaccinationbuffer period Brighton level No of casesin analysis Relative risk 95% confidenceinterval Attributable risk per million doses (95% confidence intervals)
All ages
6 months (183 days) beforevaccination to 6 monthsafter vaccination 16 weeks (112 days) Weeks 17–24(days 113–168) 1–3 13 2.07 0.70 to 6.17 0.82 [−068 to 1.32]
1–2 9 3.55 0.89 to 14.21 0.97 [−0.17 to 1.26]
No buffer 1–3 13 2.66 0.89 to 7.90 0.99 [−0.19 to 1.38]
1–2 9 4.55 1.14 to 18.21 1.06 [0.17 to 1.28]
Persons 6 months to <20 years of age
6 months (183 days) beforevaccination to 6 monthsafter vaccination 16 weeks (112 days) Weeks 17–24(days 113–168) 1–3 8 2.96 0.71 to 12.39 2.98 [−1.84 to 4.14]
1–2 5 7.10 0.79 to 63.59 3.09 [−0.96 to 3.54]
No buffer 1–3 8 3.79 0.90 to 15.89 3.31 [−0.50 to 4.22]
1–2 5 9.11 1.02 to 81.48 3.21 [0.07 to 3.56]
Persons ≥20 years of age
6 months (183 days) beforevaccination to 6 monthsafter vaccination 16 weeks (112 days) Weeks 17–24(days 113–168) 1–3 5 1.18 1.19 to 7.09 0.09 [−2.58 to 0.52]
1–2 4 1.78 0.25 to 12.61 0.26 [−1.81 to 0.56]
No buffer 1–3 5 1.52 0.25 to 9.08 0.21 [−1.81 to 0.54]
1–2 4 2.27 0.32 to 16.16 0.34 [−1.28 to 0.57]