. 2014 Sep 29;9(9):e108552. doi: 10.1371/journal.pone.0108552

Table 3. Summary estimates for the odds ratio (OR) of MTHFR C677T in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), the I² metric and publication bias p-value (Egger Test) in total studies, Asian, American and European studies.

GeneticContrast		Fixed effect OR(95% CI), p	Random effect OR(95% CI), p	Heterogeneityp-value (Q test)	I² (%)	Publication Bias(p of Egger’s test)
All	Allele Contrast (T vs. C)	1.22 (1.13−1.31), <0.0001	1.26 (1.09−1.46), 0.001	<0.0001	69.42	0.14
	Co-dominant (CT vs. CC)	1.23 (1.11−1.36), <0.0001	1.29 (1.10−1.51), 0.001	0.0002	52.49	0.02
	Homozygote (TT vs. CC)	1.44 (1.22−1.69), <0.0001	1.49 (1.13−1.97), 0.008	<0.0001	57.3	0.56
	Dominant (TT+CT vs. CC)	1.28 (1.16−1.41), <0.0001	1.35 (1.13−1.60), 0.0008	<0.0001	63.56	0.05
	Recessive (CT+CC vs. TT)	0.76 (0.65−0.88), 0.0004	0.76 (0.60−0.94), 0.01	0.0044	43.68	0.926
Asian	Allele Contrast (T vs. C)	1.53 (1.29−1.82), <0.0001	1.52 (1.09−2.1), 0.01	0.0003	69.43	0.82
	Co-dominant (CT vs. CC)	1.52 (1.21−1.91), 0.0003	1.57 (1.14−2.14), 0.005	0.09	38.05	0.11
	Homozygote (TT vs. CC)	2.41 (1.62−3.59), <0.0001	2.21 (1.03−4.74), 0.0411	0.0074	60.04	0.204
	Dominant (TT+CT vs. CC)	1.64 (1.32−2.0), <0.0001	1.70 (1.18−2.4), 0.004	0.01	56.67	0.30
	Recessive (CT+CC vs. TT)	0.54 (0.37−0.78), <0.0001	0.58 (0.29−1.16), 0.12	0.0094	58.77	0.334
American	Allele Contrast (T vs. C)	1.23 (1.07−1.39), 0.003	1.19 (0.99−1.44), 0.06	0.06	47.69	0.11
	Co-dominant (CT vs. CC)	1.42 (1.17−1.71), 0.0002	1.42 (0.97−2.06), 0.066	0.0005	73.15	0.908
	Homozygote (TT vs. CC)	1.68 (1.24−2.28), 0.0008	1.58 (0.84−2.95), 0.148	0.0007	72.07	0.667
	Dominant (TT+CT vs. CC)	1.48 (1.24−1.76), <0.0001	1.44 (0.95−2.19), 0.078	<0.0001	80.11	0.782
	Recessive (CT+CC vs. TT)	0.69 (0.51−0.92), 0.0136	0.72 (0.44−1.18), 0.203	0.0159	59.42	0.753
European	Allele Contrast (T vs. C)	1.03 (0.93−1.15), 0.482	1.04 (0.93−1.16), 0.451	0.3576	8.81	0.084
	Co-dominant (CT vs. CC)	0.99 (0.85−1.16), 0.956	1.00 (0.85−1.17), 0.992	0.3774	6.87	0.050
	Homozygote (TT vs. CC)	1.09 (0.87−1.37), 0.422	1.09 (0.85−1.40), 0.455	0.3715	7.45	0.329
	Dominant (TT+CT vs. CC)	1.02 (0.88−1.17), 0.787	1.03 (0.87−1.21), 0.704	0.308	13.58	0.041
	Recessive (CT+CC vs. TT)	0.90 (0.73−1.10), 0.322	0.90 (0.72−1.11), 0.339	0.570	0	0.948

Table 3. Summary estimates for the odds ratio (OR) of MTHFR C677T in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), the I2 metric and publication bias p-value (Egger Test) in total studies, Asian, American and European studies.

Table 3. Summary estimates for the odds ratio (OR) of MTHFR C677T in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), the I² metric and publication bias p-value (Egger Test) in total studies, Asian, American and European studies.