Table 2.
Estimated Differences (LSmean±SE, 95% Confidence Interval, p-value) in Pain Levels in knees Between Women and Men by KL Grade.
| KL Grade | Unadjusted* | Adjusted** | Adjusted*** | |||
|---|---|---|---|---|---|---|
| VAS Pain (0–100) | ||||||
| <2 n=3365 |
4.2±0.7 (2.8–5.7) |
<0.0001 | 3.3±0.7 (1.9–4.6) |
<0.0001 | 2.1±0.7 (0.8–3.5) |
0.0015 |
| 2 n=852 |
5.3±1.6 (2.1–8.5) |
0.0015 | 4.6±1.5 (1.6–7.6) |
0.0036 | 3.5±1.5 (0.6–6.4) |
0.0200 |
| 3 n=838 |
6.4±1.8 (2.9–10.0) |
0.0004 | 4.2±1.7 (0.8–7.5) |
0.0151 | 3.2±1.7 (−0.1–6.6) |
0.0566 |
| 4 n=369 |
7.6±2.6 (2.5–12.7) |
0.0038 | 5.0±2.5 (0.1–9.9) |
0.0472 | 4.4±2.5 (−0.5–9.3) |
0.0792 |
| WOMAC Pain (0–100%) | ||||||
| <2 n=3365 |
3.6±0.6 (2.3–4.9) |
<0.0001 | 2.6±0.6 (1.4–3.7) |
<0.0001 | 1.5±0.6 (0.3–2.6) |
0.0115 |
| 2 n=852 |
4.8±1.4 (2.1–7.5) |
0.0007 | 4.2±1.3 (1.6–6.7) |
0.0016 | 3.1±1.2 (0.7–5.6) |
0.0128 |
| 3 n=838 |
6.0±1.5 (3.0–9.1) |
0.0001 | 3.9±1.4 (1.1–6.7) |
0.0059 | 2.8±1.4 (0.1–5.6) |
0.0436 |
| 4 n=369 |
3.9±2.1 (−0.1–8.0) |
0.0605 | 1.3±1.9 (−2.5–5.1) |
0.4932 | 0.8±2.0 (−3.0–4.7) |
0.6699 |
BMI: Body Mass Index
KL: Kellgren-Lawrence
LSMean: Least Squares Means
SE: Standard Error
VAS: Visual Analog Scale
WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index
*
Adjusted for contralateral knee KL grade
**
Adjusted for age, BMI, depression score, education, clinic site, race, comorbid conditions and analgesic medication use
***
Further adjusted for presence of widespread pain