Table 1. Diverse and representative peptide set.
Peptide | Sequence | Length | Details | Strain/Clade | Genebank ID | Origin |
1 | LRDKKQRVYSLFYKLDVVQIN | 21 amino acids | Highest polarity V2 most soluble | QB585.2102M.Ev1v5.C Clade A | ACS26794 | Kenya |
2 | IRDKVQKEYALFYKLDVVPID | 21 amino acids | Most commonly occurring | 878v3_2475Clade B | EU184191 | US |
3 | LRDKKQQVYSLFYRLDIEKIN | 21 amino acids | Highest polarity of most common length | 01TZA341Clade A | AY253314 | Tanzania |
4 | IRDKKQKEYALFYKLDVVPID | 21 amino acids | Published consensus V2 | N/A | N/A | N/A |
The sequences of the four peptides selected to represent the V2 loop region for a variety of HIV-1 viruses. Peptide 1 represents the most polar V2 peptide, Peptide 2 the most commonly occurring peptide, Peptide 3 the most polar peptide of the most common length, and Peptide 4 the published consensus V2 peptide.