Table 1.
Association of Immunoglobulin A nephropathy (IgAN) susceptibility loci with lupus nephritis (LN) in the Beijing discovery cohort.
| SNP | Chr. | Bp | Candidate Gene | Minor Allele | Frequency (Case/Control %) | P | OR (95% CI) in LN | OR in IgAN | Ref. |
|---|---|---|---|---|---|---|---|---|---|
| rs6677604 | 1 | 194953541 | CFH | A | 7.36/7.45 | 0.94 | (11) | ||
| rs2523946 | 6 | 30049922 | HLA-A | C | 50.30/48.59 | 0.45 | (10) | ||
| rs660895 | 6 | 32685358 | HLA-DRB1 | G | 12.60/19.01 | 8.97×10−5 | 0.61 (0.48–0.79) | 1.34 | (10) |
| rs2856717 | 6 | 32778286 | HLA-DQB1 | T | 33.06/24.14 | 1.09×10−5 | 1.55 (1.28–1.89) | 0.73 | (11) |
| rs1794275 | 6 | 32779226 | HLA-DQB1 | T | 14.68/12.90 | 0.25 | (10) | ||
| rs9275596 | 6 | 32789609 | HLA-DQB1 | C | 29.33/20.82 | 1.22×10−5 | 1.58 (1.29–1.94) | 0.63 | (11) |
| rs9357155 | 6 | 32917826 | PSMB8 | A | 23.08/19.62 | 0.06 | 1.23 | 0.71 | (11) |
| rs2071543 | 6 | 32919607 | PSMB8 | A | 24.60/20.93 | 0.05 | 1.23 | 0.73 | (11) |
| rs3129269 | 6 | 33205592 | HLA-DPB2 | T | 25.81/26.16 | 0.86 | (11) | ||
| rs2738058 | 8 | 6810195 | DEFA | G | 33.87/31.79 | 0.32 | (10) | ||
| rs3803800 | 17 | 7403693 | TNFSF13 | A | 30.54/32.60 | 0.33 | (10) | ||
| rs12537 | 22 | 28753460 | MTMR3 | T | 25.10/29.28 | 3.66×10−2 | 0.81 (0.66–0.98) | 0.78 | (10) |
| rs9983 | 22 | 28753744 | MTMR3 | A | 11.49/7.45 | 2.07×10−3 | 1.61 (1.19–2.19) | 1.18 | (11) |
| rs2412971 | 22 | 28824371 | HORMAD2 | A | 36.39/40.24 | 0.08 | 0.85 | 0.75 | (11) |
| rs2412973 | 22 | 28859631 | HORMAD2 | A | 36.79/40.14 | 0.13 | (11) |
Only associations with statistical significance or marginal significance are presented with OR values. Ninety-five percent confidence intervals are shown for significant associations.