Table 3.

Impact of neonatal infection on white matter injury and death

	Unadjusted odds ratio (95% CI)	* Adjusted odds ratio (95% CI)	† Adjustment including TPN and vent (95% CI)
	P value	P value	P value
Intraventricular hemorrhage
Sepsis	5.2 (1.3, 20.9)	5.8 (1.3, 24.8)	4.9 (0.8, 29.3)
	0.02	0.02	0.08
Necrotizing enterocolitis	6.4 (1.1–38.4)	6.2 (1.0, 37.7)	14.1 (1.4, 138.0)
	0.04	0.05	0.02
Clinically suspected infection	3.0 (0.6, 14.7)	3.1 (0.6, 15.6)	4.1 (0.6, 26.1)
	0.175	0.165	0.133
Cerebellar hemorrhage
Sepsis	3.6 (1.0, 12.5)	3.5 (1.0, 12.4)	1.8 (0.4, 8.6)
	0.05	0.05	0.5
Necrotizing enterocolitis	3.8 (0.5, 26.4)	3.9 (0.5, 27.9)	N/A
	0.177	0.182	0.999
Clinically suspected infection	8.4 (2.3, 30.9)	8.5 (2.3, 30.8)	6.2 (1.5, 25.9)
	0.001	0.001	0.01
Any injury or death
Sepsis	8.1 (2.5, 25.6)	8.5 (2.6, 27.7)	6.5 (1.6, 26.5)
	< 0.001	< 0.001	0.009
Necrotizing enterocolitis	10.1 (1.7, 59.1)	10.1 (1.7, 59.1)	10.7 (1.6, 72.6)
	0.01	0.01	0.02
Clinically suspected infection	13.3 (3.7, 47.6)	14.0 (3.8, 51.6)	10.7 (2.5, 44.8)
	< 0.001	0.001	0.001

^*adjustment model includes PMA

^†adjustment model includes PMA, days of TPN, and days of ventilation