Table 4.
Impact of proven neonatal sepsis on brain metrics and diffusion measures
| Unadjusted means | * Adjusted means | † Adjusted mean including TPN and vent | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Control (SE) | Sepsis (SE) | P value | Control (SE) | Sepsis (SE) | P value | Control (SE) | Sepsis (SE) | P value | |
|
Brain metrics (cm)
**
| |||||||||
| Bifrontal diameter | 59.8 (0.9) | 56.3 (2.7) | 0.224 | 60.7 (1.1) | 55.8 (3.0) | 0.141 | 60.0 (1.8) | 56.0 (3.5) | 0.367 |
| Biparietal diameter | 70.4 (0.9) | 63.5 (2.7) | 0.02 | 72.2 (1.0) | 62.6 (2.7) | 0.002 | 71.4 (1.6) | 63.3 (3.1) | 0.046 |
| Interhemispheric diameter | 3.7 (0.3) | 3.7 (1.0) | 0.959 | 3.9 (0.4) | 3.0 (1.1) | 0.455 | 3.7 (0.7) | 3.3 (1.3) | 0.822 |
| Transcerebellar diameter | 48.4 (0.7) | 38.3 (2.2) | < 0.001 | 49.5 (0.8) | 36.8 (2.3) | < 0.001 | 49.7 (1.4) | 37.0 (2.7) | 0.001 |
| Right ventricular diameter | 8.1 (0.6) | 11.9 (1.8) | 0.046 | 7.6 (0.7) | 12.5 (2.0) | 0.027 | 8.1 (1.0) | 13.6 (2.0) | 0.038 |
| Left ventricular diameter | 8.0 (0.4) | 12.0 (1.3) | 0.005 | 8.0 (0.5) | 12.3 (1.4) | 0.007 | 8.5 (0.7) | 13.0 (1.4) | 0.01 |
|
| |||||||||
|
Diffusion (× 10-3 mm2/s)
| |||||||||
| Right Frontal Lobe | |||||||||
| Mean diffusion | 1.71 (0.02) | 1.79 (0.04) | 0.17 | 1.69 (0.03) | 1.79 (0.05) | 0.05 | 1.70 (0.04) | 1.83 (0.05) | 0.02 |
| Axial diffusion | 1.93 (0.02) | 2.02 (0.05) | 0.12 | 1.90 (0.03) | 2.02 (0.05) | 0.04 | 1.90 (0.04) | 2.05 (0.05) | 0.01 |
| Radial diffusion | 1.61 (0.02) | 1.67 (0.05) | 0.22 | 1.58 (0.03) | 1.68 (0.05) | 0.07 | 1.60 (0.04) | 1.72 (0.05) | 0.04 |
| Left Frontal Lobe | |||||||||
| Mean diffusion | 1.71 (0.02) | 1.79 (0.04) | 0.07 | 1.68 (0.02) | 1.82 (0.04) | 0.004 | 1.68 (0.03) | 1.85 (0.04) | 0.001 |
| Axial diffusion | 1.93 (0.02) | 2.03 (0.04) | 0.04 | 1.90 (0.02) | 2.05 (0.04) | 0.003 | 1.88 (0.03) | 2.07 (0.04) | < 0.001 |
| Radial diffusion | 1.60 (0.02) | 1.67 (0.04) | 0.12 | 1.57 (0.02) | 1.70 (0.04) | 0.007 | 1.58 (0.03) | 1.74 (0.04) | 0.001 |
| Right Cingulum Bundle | |||||||||
| Mean diffusion | 1.46 (0.01) | 1.5 (0.02) | 0.08 | 1.46 (0.01) | 1.51 (0.02) | 0.04 | 1.45 (0.01) | 1.52 (0.02) | 0.002 |
| Axial diffusion | 2.01 (0.02) | 2.04 (0.04) | 0.42 | 2.00 (0.02) | 2.06 (0.04) | 0.12 | 1.99 (0.03) | 2.07 (0.04) | 0.09 |
| Radial diffusion | 1.19 (0.01) | 1.23 (0.02) | 0.18 | 1.19 (0.02) | 1.23 (0.03) | 0.21 | 1.18 (0.02) | 1.24 (0.03) | 0.03 |
*
adjustment model includes PMA at scan, gender, and race
†
adjustment model additionally includes upper quartiles of days of TPN and days of ventilation
**
Brain metrics compared infants with both sepsis and NEC