Table 1.
Association of seven transethnic SNPs with type 2 diabetes in longitudinally studied participants from the Gila River Indian Community
| SNP | Locusa | Allelea(R/NR) | Longitudinally studied American Indians | Transethnic meta-analysis GWASa | Powerf (N = 7,710) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RAF | T2Db (N = 7,710) | BMIc (N = 6,839) | T2D (adjmaxBMI)d (n = 6,587) | T2D | |||||||||
| OR (95% CI)a | p | β | p | OR (95% CI) | p | RAFa,e | OR (95% CI) | p | |||||
| rs17106184 | FAF1 | G/A | 0.992 | 1.29 (0.78, 2.14) | 0.32 | 0.003 | 0.88 | 1.24 (0.75, 2.06) | 0.4 | 0.58–0.95 | 1.10 (1.07, 1.14) | 4.1 × 10−9 | 0.11 |
| rs6808574 | LPP | C/T | 0.966 | 0.90 (0.67, 1.21) | 0.49 | −0.025 | 0.06 | 0.93 (0.68, 1.27) | 0.63 | 0.60–0.98 | 1.07 (1.04, 1.09) | 5.8 × 10−9 | 0.18 |
| rs6813195 | TMEM154 | C/T | 0.53 | 1.12 (1.03, 1.22) | 0.01 | −0.007 | 0.08 | 1.13 (1.03, 1.23) | 0.007 | 0.39–0.71 | 1.08 (1.06, 1.10) | 4.1 × 10−14 | 0.91 |
| rs702634 | ARL15 | A/G | 0.963 | 0.87 (0.67, 1.14) | 0.31 | −0.003 | 0.82 | 0.88 (0.66, 1.15) | 0.35 | 0.67–0.86 | 1.06 (1.04, 1.09) | 6.9 × 10−9 | 0.16 |
| rs9505118 | SSR1–RREB1 | A/G | 0.56 | 1.08 (0.99, 1.18) | 0.08 | 0.001 | 0.78 | 1.08 (0.99, 1.18) | 0.1 | 0.35–0.75 | 1.06 (1.04, 1.08) | 1.4 × 10−9 | 0.71 |
| rs3130501 | POU5F1–TCF19 | G/A | 0.63 | 1.08 (0.99, 1.18) | 0.08 | −0.012 | 0.004 | 1.11 (1.02, 1.22) | 0.02 | 0.43–0.76 | 1.07 (1.04, 1.09) | 4.2 × 10−9 | 0.8 |
| rs4275659 | MPHOSPH9 | C/T | 0.47 | 0.99 (0.90, 1.08) | 0.77 | 0.005 | 0.28 | 0.99 (0.91, 1.08) | 0.82 | 0.53–0.78 | 1.06 (1.04, 1.08) | 9.5 × 10−9 | 0.73 |
aData derived from the genome-wide transethnic meta-analysis report [1]
bT2D association was analysed in 3,625 full-heritage Pima Indians and 4,085 mixed-heritage American Indians who had some degree of American Indian heritage (on average a person’s heritage was two-thirds American Indian), the p value and OR (95% CI) were adjusted for age, sex, birth year, family membership and admixture estimates
cMaximum recorded lifetime BMI (age ≥15 years) was used for the BMI association analysis, p values were adjusted for age, sex, birth year, family membership and admixture estimates, β coefficients represent the effect on a logarithmic scale per copy of the risk allele
d p values and ORs (95% CI) for T2D association were also adjusted for maximum lifetime BMI (adjmaxBMI) in participants who were defined for both T2D and BMI
eRAF ranges for the lead SNPs at the respective loci in Europeans, East Asians, South Asians, Mexicans and Mexican Americans
fThe power of the current study to detect an effect size for T2D similar to the transethnic meta-analysis study calculated using the RAF and diabetes prevalence in American Indians
NR, non-risk allele; R, risk allele based on genome-wide transethnic meta-analysis [1], T2D, type 2 diabetes