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Simulated rivaroxaban plasma concentration–time profiles for a virtual population of patients with atrial fibrillation (with permission [56]). For patients with mildly impaired or normal CrCl (>50 mL/min), exposure is the same with a 20 mg od dose as for patients with moderate renal impairment (≤50 mL/min) with a 15 mg od dose. CrCl creatinine clearance, od once daily
