Table 2.
Physical properties of polyplex nanoparticles formed from DNA (pGL4.13) and lactone-DES-MDEA terpolymer.
| Polymer name* | N/P† (molar ratio) |
Mean particle radius (nm) |
Zeta potential (mV) |
|---|---|---|---|
| PMSC‡ | 116 | 70 | 15.7 |
| I-10%CL | 111 | 73 | 11.3 |
| I-20%CL | 105 | 107 | 10.8 |
| I-40%CL | 91 | 45 | 15.3 |
| I-60%CL | 72 | 43 | 16.7 |
| I-80%CL | 45 | 117 | 7.3 |
| II-10%DDL | 107 | 69 | 10.4 |
| II-20%DDL | 99 | 93 | 11.6 |
| II-40%DDL | 79 | 90 | 8.9 |
| III-10%PDL | 106 | 86 | 13.2 |
| III-20%PDL | 96 | 75 | 8.9 |
| IV-10%HDL | 105 | - | - |
See Table 1 for polymer nomenclature.
All polyplex nanoparticles were formed at 100:1 weight ratio (polymer/DNA).
PMSC is included here as a reference polymer.