Figure 5.

Inhibition of RXRα Modulates Gene Expression in Infected and Inflamed KCs

(A) Mice were treated with HX531 or saline and then infected.

(B–P) After 12 hr, infected (red) and inflamed (black) KCs were isolated to determine the relative mRNA accumulation of Rxra (B), Cebpa (C), Vamp4 (D), Vdr (E), LXRα (F), LXRβ (G), Rara (H), Pparγ (I), Abca1 (J), Abcg1 (K), ApoE (L), Cyp27a1 (M), Cyp27b1 (N), IL-1β (O), and iNos (P) expressed as the relative expression compared to KC isolated from sham-infected control mice (relative expression of 1). Individual symbols represent cells isolated from pools of four mice, sorted independently. Data are represented as mean ± SEM. Data were analyzed using one-way ANOVA with Tukey’s post test. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. See also Figure S2.