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. 2013 Sep 11;14(3):357–368. doi: 10.1016/j.chom.2013.08.004

Figure 6.

Figure 6

Therapeutic Targeting of RXRα Impairs L. donovani Survival within Macrophages

(A) Mice were pretreated with HX531, LG268, GW3965, or saline and infected 2–6 hr later. Parasite burdens were determined after 2 hr and 96 hr.

(B and C) Number of parasites present in the spleen (B) and liver (C) 96 hr after infection, as measured by flow cytometry.

(D and E) The fold increase in parasite burden relative to the 2 hr time point in the spleen (D) and liver (E).

(F) The percentage of KCs infected at 96 hr determined by fluorescence microscopy.

(G) The percentage of KCs infected at 96 hr relative to the percent infected at 2 hr. Individual symbols represent individual mice, and data are representative of three independent experiments for HX531 treatment and control groups and 1 experiment for LG268 and GW3965 treatments. Data are represented as mean ± SEM.