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. 2014 Sep 29;9(9):e108351. doi: 10.1371/journal.pone.0108351

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© 2014 Ji et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Altered proteins that are involved in metabolism processes related to de novo lipid synthesis: aconitase 2 (ACO2) and malate dehydrogenase (MDH2), which participate in tricarboxylic acid cycle (TAC) (i) decreased; ATP-citrate synthase (ACLY), the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA (ii) decreased; 5′-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) that repress the synthesis of malonyl-CoA (iii) by phosphorylation of acetyl-CoA carboxylase increased; glucose 1-dehydrogenase/6-phosphogluconolactonase (H6PD), the rate-limiting enzyme in pentose phosphate pathway (PPP) (iv) decreased; 6-phosphofructokinase type C (PFKP) that acts as the rate-limiting enzyme, fructose-bisphosphate aldolase C (ALDOC), which are involved in glycolytic pathway(v) decreased.