Table 3. Avidity index of OprF/I-specific IgG antibodies at day 7 and day 14 by treatment group (per protocol population; subgroup of subjects with detectable OprF/I-specific IgG antibodies at day 7 and day 14).
| Day | Statistic | IC43 100 µg (n = 5) |
IC43 100 µg w/o (n = 11) |
IC43 200 µg (n = 7) |
IC43 50 µg (n = 3) |
|---|---|---|---|---|---|
| 7 | Median | 0.64 | 0.93 | 1.49 | 0.10 |
| IQR | 0.59 − 1.87 | 0.71 − 1.23 | 1.12 − 2.72 | 0.10 − 2.03 | |
| 14 | Median | 1.56 | 1.45 | 2.55 | 0.10 |
| IQR | 0.85 − 2.43 | 0.89 − 2.19 | 1.91 − 3.16 | 0.10 − 2.82 |
Note: An index of low (defined as >50% stripping with a concentration of 0.5 M ammonium thiocyanate) was set to 0.1 M; an index of high (<50% stripping with 4 M ammonium thiocyanate) was set to 4.5 M. IgG, immunoglobulin G; IQR, interquartile range; OprF/I, outer membrane protein OprF/I hybrid vaccine; w/o, without adjuvant.